The Hepatitis D Virus

THIS REVIEW was written by Howard J. Worman, M.D., Departments of Medicine and of Anatomy and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032. Dr. Worman has more reviews available at his Current Papers in Liver Disease site. Hepatitis B By Howard J. Worman, M. D. Chang, M.-H., Chen, C.-J., Lai, M.-S., Hsu, H.-M., Wu, T.-C., … Read more

Interferon alfa therapy for chronic hepatitis B in children: a multinational randomized controlled trial

Gastroenterology. 114:988-99 Interferon alpha is effective in the treatment of chronic hepatitis B in adults and is approved for this indication in the United States and several other countries. Its safety and efficacy has not been as carefully evaluated in children. This trial at several centers in Canada, Europe and the United States examined the … Read more

Treatment of Chronic Hepatitis B

Dr. Sherman is a Hepatologist practicing in Toronto, Canada. This paper has been submitted as a contribution to the Update in Liver Disease Conference 1998 and discusses current and future therapies for hepatitis B. (Some clinical information related to lamivudine has been omitted until data publication). Dr. Morris Sherman The first licensed therapy for chronic hepatitis … Read more

Specific Immunotherapy for the Control of Hepatitis B Virus Multiplication

Key Learning Objectives At the end of the session, the participants will be able to: define the concept of “specific immunotherapy” clearly delineate its potential side effects update the literature on data obtained with current vaccines define new strategies and, in particular, the concept of “DNA vaccination” summarize the data available with DNA vaccines for … Read more

Hepatitis – Zeffix treatment

BioChem Pharma Inc. announced that new Zeffix data were presented today at the European Association for the Study of the Liver (EASL) congress, in Rotterdam. Lifetime treatment of a chronic illness is a daunting prospect-for patient, physician and budget holders. It can also prove to be a major hurdle to effective treatment. In the case … Read more

Hepatitis B InfoCenter

THIS PAGE contains links to a variety of Hepatitis B information and news. This information is updated periodically. For easier navigation, this page has been subdivided into Publications, Papers, etc., and News Reports. All papers are copyright and permission for reproduction must be granted. Publications, Papers and Websites December 3, 2000: According to Toronto’s Sunday Star, ”Canada, concerned … Read more

The Liver in Health

The characteristic structure and organization of the liver enables it to perform vital roles in regulating, synthesizing, storing, secreting, transforming, and breaking down many different substances in the body. In addition, the liver’s ability to regenerate lost tissue helps maintain these functions, even in the face of moderate damage. This section of the module focuses on … Read more

Liver Functions

The characteristic structure and organization of the liver enable it to perform vital roles in regulating, synthesizing, storing, secreting, transforming, and breaking down many different substances in the body. In addition, the liver’s ability to regenerate lost tissue helps maintain these functions, even in the face of moderate damage. This section of the module focuses … Read more

The Liver in Disease

As you have learned, the liver is responsible for many essential functions. Because of these activities, it is exposed to a wide variety of insults and is therefore one of the most frequently injured organs in the body. The impairment of these vital functions by hepatic disease leads to clinical manifestations that are often similar, regardless … Read more

Assessment of Liver Dysfunction

As discussed in the previous section, liver injury from a variety of causes can lead to very similar clinical symptoms, a common endpoint being hepatocyte damage and scar formation. However, a thorough history and physical examination can reveal clues to the potential etiologies of liver disease. Laboratory studies can help establish the pattern of injury, the … Read more